1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine, Dihydrochloride

CAS: 203911-27-7

Ref. TR-I882200

Produktinformation

• Name: 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine, Dihydrochloride
• Synonyme: HA1077, Fasudil Dihydrochloride
• Marke: TRC

Beschreibung

Applications A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced contraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho-associated Kinase (ROCK IC50= 10.7 uM).
References Hidaka, H., et al.: Acta Nurochir. (Wien), 90 (1988) Sward., K., el a.: J. Physiol., 522, 33 (2000),

Chemische Eigenschaften

• Molekulargewicht: 364.29056
• Formel: C₁₄H₁₇N₃O₂S·2HCl
• Farbe/Form: Neat
• InChl: InChI=1S/C14H17N3O2S.2ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;;/h1,3-5,7,11,15H,2,6,8-10H2;2*1H
• InChI Key: InChIKey=NGOGFTYYXHNFQH-UHFFFAOYSA-N
• SMILES: O=S(=O)(c1cccc2cnccc12)N1CCCNCC1