1-(2,4-Dichlorobenzoyl)-1H-benzotriazole

CAS: 200626-61-5

Ref. TR-I937560

Produktinformation

• Name: 1-(2,4-Dichlorobenzoyl)-1H-benzotriazole
• Synonyme: 1H-Benzotriazol-1-yl(2,4-dichlorophenyl)-methanone, ITSA-1, Methanone, 1H-1,2,3-benzotriazol-1-yl(2,4-dichlorophenyl)-, 1H-Benzotriazol-1-yl(2,4-dichlorophenyl)methanone

Beschreibung

Applications Histone deacetylase (HDAC) inhibitors are able to interrupt cell cycle progression in transformed cell lines and may be explored as new clinical agents in cancer therapy. 1-(2,4-Dichlorobenzoyl)-1H-benzotriazole has been shown to suppress the biological effects induced by the HDAC inhibitor, Trichostatin A (T774710).
References Koeller, K. M., et al.: Chem. Biol. 10, 397 (2003); Vigushin, D., et al.: Clin. Cancer Res. 7, 971 (2001)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 292.12
• Formel: C₁₃H₇Cl₂N₃O
• Farbe/Form: Neat
• InChl: InChI=1S/C13H7Cl2N3O/c14-8-5-6-9(10(15)7-8)13(19)18-12-4-2-1-3-11(12)16-17-18/h1-7H
• InChI Key: InChIKey=UVNLAUGZMOPBPR-UHFFFAOYSA-N
• SMILES: O=C(c1ccc(Cl)cc1Cl)n1nnc2ccccc21