JT010

CAS: 917562-33-5

Ref. TR-J212028

Produktinformation

• Name: JT010
• Synonyme: 2-Chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)acetamide
• CAS: 917562-33-5

Beschreibung

Applications JT010 is a potent and selective TRPA1 channel activator (EC50 = 65 nM); activates the TRPA1 channel by covalently and site-selectively binding to Cys621. Exhibits selectivity for TRPA1 over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50 values are >1 μM).
References Takaya, Junichiro., et al.: J. Am. Chem. Soc., 137, 15859 (2015);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 354.85
• Formel: C₁₆H₁₉ClN₂O₃S
• Farbe/Form: Off-White to Light Beige Solid
• InChl: InChI=1S/C16H19ClN2O3S/c1-21-9-3-8-19(15(20)10-17)16-18-14(11-23-16)12-4-6-13(22-2)7-5-12/h4-7,11H,3,8-10H2,1-2H3
• InChI Key: InChIKey=KZMAWJRXKGLWGS-UHFFFAOYSA-N
• SMILES: COCCCN(C(=O)CCl)c1nc(-c2ccc(OC)cc2)cs1