(-)-a-Kainic Acid

CAS: 487-79-6

Ref. TR-K135010

Produktinformation

• Name: (-)-a-Kainic Acid
• Synonyme: (2S,3S,4S)-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic Acid, 2-Carboxy-4-isopropenyl-3-pyrrolidineacetic Acid, (-)-Kainic Acid, (2S,3S,4S)-2-Carboxy-4-isopropenylpyrrolidine-3-acetic Acid, Digenic Acid, Digenin, Helminal, Kainic Acid, L-α-Kainic Acid
• Marke: TRC

Beschreibung

Applications (-)-α-Kainic Acid is a naturally occurring neuroexcitatory chemical that is an selective agonist for a subtype of ionotropic glutamate receptor. Administration of (-)-α-Kainic Acid has been shown to increase production of reactive oxygen species, mitochondrial dysfunction, and apoptosis in neurons in many regions of the brain, particularly in the hippocampal subregions and in the hilus of dentate gyrus.
References Wacker, D.A., et al.: Synlett, 503 (1997), Dunleavy, M., et al.: J. Molec. Neurosci., 49, 202 (2013); Zhang, J., et al.: Neuron., 76, 1133 (2012); Yamada, J., et al.: Neurosci., 226, 119 (2012); Wang,Q., et al.: Mol. Neurobiol., 31, 3 (2005)’

Chemische Eigenschaften

• Molekulargewicht: 213.23
• Formel: C₁₀H₁₅NO₄
• Farbe/Form: Neat
• InChl: InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1