(-)-α-Kainic Acid Lithium Salt

CAS: 487-79-6

Ref. TR-K135015

Produktinformation

• Name: (-)-α-Kainic Acid Lithium Salt
• Synonyme: Lithium 2-((2S,3S,4S)-2-carboxy-4-(prop-1-en-2-yl)pyrrolidin-3-yl)acetate, (-)-α-Kainic acid, (2-Carboxy-4-isopropenyl-3-pyrrolidinyl)-essigsaeure anhydrous, (2S,3S,4S)-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid, (2S,3S,4S)-2-Carboxy-4-isopropenylpyrrolidine-3-acetic acid, (3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-yl-L-proline, 3-(Carboxymethyl)-4-Prop-1-En-2-Ylproline, 3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethenyl)-, (2S,3S,4S)-, 3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethenyl)-, [2S-(2α,3β,4β)]-, 3-Pyrrolidineacetic acid, 2-carboxy-4-isopropenyl-, <span class="text-smallcaps">L</span>-α-Kainic acid, Digenic acid, Digenin, Helminal, L-α-Kainic acid

Beschreibung

Applications (-)-α-Kainic Acid Lithium Salt is a naturally occurring neuroexcitatory chemical that is an selective agonist for a subtype of ionotropic glutamate receptor. Administration of (-)-α-Kainic Acid has been shown to increase production of reactive oxygen species, mitochondrial dysfunction, and apoptosis in neurons in many regions of the brain, particularly in the hippocampal subregions and in the hilus of dentate gyrus.
References Wacker, D.A., et al.: Synlett, 503 (1997), Dunleavy, M., et al.: J. Molec. Neurosci., 49, 202 (2013); Zhang, J., et al.: Neuron., 76, 1133 (2012); Yamada, J., et al.: Neurosci., 226, 119 (2012); Wang,Q., et al.: Mol. Neurobiol., 31, 3 (2005)’

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 219.163
• Formel: C₁₀H₁₄LiNO₄
• Farbe/Form: Neat
• InChl: InChI=1S/C10H15NO4.Li/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13;/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15);/q;+1/p-1/t6-,7+,9-;/m0./s1
• InChI Key: InChIKey=NOUMCWSOFPNXAY-SLGZUKMRSA-M
• SMILES: [Li]OC(=O)C[C@H]1[C@@H](C(=C)C)CN[C@@H]1C(=O)O