3α-Hydroxy-7-oxocholanoyltaurine

CAS: 75808-01-4

Ref. TR-K175030

Produktinformation

• Name: 3α-Hydroxy-7-oxocholanoyltaurine
• Synonyme: 2-[[(4R)-4-[(3R,5S,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-7-oxo-1,2,3,4,5,6,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid, 7-Oxolithocholic acid-taurine conjugate, 7-Ketolithocholic acid-taurine conjugate, Ethanesulfonic acid, 2-[[(3α,5β)-3-hydroxy-7,24-dioxocholan-24-yl]amino]-, 2-[[(3α,5β)-3-Hydroxy-7,24-dioxocholan-24-yl]amino]ethanesulfonic acid

Beschreibung

Applications 7-Ketolithocholic Acid-taurine Conjugate is a bile acid conjugate and metabolite of Taurolithocholic Acid (T009100) with antiinflammatory activity. Taurochenodeoxycholic Acid has been shown to inhibit hepatocyte apoptosis through suppression of Bid translocation to mitochondria.
References Emerman, S. et al.: J. Biol. Chem., 242, 661 (1967); Takikawa, Y. et al.: Falk Symp., 120, 249 (2001); Li, P. et al.: Zhong. Shour. Xue., 28, 1317 (2008);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 497.688
• Formel: C₂₆H₄₃NO₆S
• Farbe/Form: Neat
• InChl: InChI=1S/C26H43NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-21,24,28H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20+,21+,24+,25+,26-/m1/s1
• InChI Key: InChIKey=QNRIYEYAHVEGQJ-SWQVIYSDSA-N
• SMILES: C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3C(=O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C