KP372-1

CAS: 1374996-60-7

Ref. TR-K658800

Produktinformation

• Name: KP372-1
• Synonyme: 6H-Indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one compound with 10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one

Beschreibung

Applications KP372-1 is a specific Akt inhibitor that demonstrates at least 10-fold selectivity against a panel of additional kinase targets, including CDK1, ERK1, GSK3β, LCK, MEK1, PKA, PKC, and S6K. By blocking Akt signaling, KP372-1 has been shown to inhibit proliferation and to induce apoptosis of thyroid cancer cells.
References Zeng, Z., et al.: Cancer Res, 66, 3737-3746 (2006); Mandal, M., et al.: Br. J. Cancer, BJC, 92, 1899-1905 (2005)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 448.36
• Formel: C₁₀H₄N₆O·C₁₀H₄N₆O
• Farbe/Form: Neat
• InChl: InChI=1S/2C10H4N6O/c17-9-6-4-2-1-3-5(6)7-8(9)11-10-12-14-15-16(10)13-7;17-9-6-4-2-1-3-5(6)7-8(9)13-16-10(11-7)12-14-15-16/h2*1-4H
• InChI Key: InChIKey=CWFOAASSUQIXOW-UHFFFAOYSA-N
• SMILES: O=C1c2ccccc2-c2nc3nnnn3nc21.O=C1c2ccccc2-c2nn3nnnc3nc21