KRN 633

CAS: 286370-15-8

Ref. TR-K659500

Produktinformation

• Name: KRN 633
• Synonyme: 1-(2-Chloro-4-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-3-propylurea, Krn-633, 1-(2-Chloro-4-(6,7-Dimethoxyquinazolin-4-Yloxy)Phenyl)-3-Propylurea, Krn633

Beschreibung

Applications KRN 633 is an ATP-competitive inhibitor of vascular endothlial growth factor receptor tyrosine kinase (VEGFR). KRN 633 also suppresses VEGF-dependent activation of MAPK and cell proliferation and demonstrates antitumor and antiangiogenic activity by inhibiting vessel formation and vascular permeability in human tumor xenograft models.
References Fediriv, O., et al.: Proc. Natl. Acad. Sci. USA, 104, 20523 (2007); Nakamura, K., et al.: Mol. Cancer. Ther., 3, 1639 (2004)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 416.86
• Formel: C₂₀H₂₁ClN₄O₄
• Farbe/Form: Off-White Solid
• InChl: InChI=1S/C20H21ClN4O4/c1-4-7-22-20(26)25-15-6-5-12(8-14(15)21)29-19-13-9-17(27-2)18(28-3)10-16(13)23-11-24-19/h5-6,8-11H,4,7H2,1-3H3,(H2,22,25,26)
• InChI Key: InChIKey=VPBYZLCHOKSGRX-UHFFFAOYSA-N
• SMILES: CCCNC(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1Cl