(S)-Laudanosine

CAS: 2688-77-9

Ref. TR-L178525

Produktinformation

• Name: (S)-Laudanosine
• Synonyme: (1S)-1-[(3,4-Dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinoline, Laudanosine, (+)-Laudanosine, L-(+)-Laudanosine, L-Laudanosine, (+)-Laudanosine, NSC 35045, O-Methylcodamine, (1S)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline, (1S)-1-[(3,4-Dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinoline, (S)-(+)-Laudanosine, 1-(3,4-Dimethoxybenzyl)-6,7-Dimethoxy-2-Methyl-1,2,3,4-Tetrahydroisoquinoline, <span class="text-smallcaps">L</span>-(+)-Laudanosine, DL-6,7-dimethoxy-1-((3,4-dimethoxyphenyl)methyl)-2-methylisoquinoline, DL-laudanosine, Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (1S)-, Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (S)-

Beschreibung

Applications Laudanosine is a metabolite of the neuromuscular-blocking drugs Atracurium (A794500) and Cisatracurium (C496700) with potentially toxic systemic effects. It crosses the blood-brain barrier and may cause excitement and seizure activity.
References Canfell, P., et al.: Drug Metab. Dispos., 14, 703 (1986), Anselmi, E., et al.: J. Pharm. Pharmacol., 44, 337 (1992), Bohrer, H., et al.: Pharmacol. Toxicol., 73, 137 (1993),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 357.44
• Formel: C₂₁H₂₇NO₄
• Farbe/Form: Neat
• InChl: InChI=1S/C21H27NO4/c1-22-9-8-15-12-20(25-4)21(26-5)13-16(15)17(22)10-14-6-7-18(23-2)19(11-14)24-3/h6-7,11-13,17H,8-10H2,1-5H3/t17-/m0/s1
• InChI Key: InChIKey=KGPAYJZAMGEDIQ-KRWDZBQOSA-N
• SMILES: COc1ccc(C[C@H]2c3cc(OC)c(OC)cc3CCN2C)cc1OC