trans-Loperamide N-Oxide

CAS: 106900-12-3

Ref. TR-L469460

Produktinformation

• Name: trans-Loperamide N-Oxide
• Synonyme: Arestal, Loperamide oxide, R 58425,Loperamide Oxide, Loperamide Hydrochloride Imp. F (EP), trans-4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide 1-oxide
• Marke: TRC
• Beschreibung: Stability HygroscopicApplications Loperamide oxide (LOPOX) is a prodrug of Loperamide (LOP). It is concluded that Loperamide oxide administered intraluminally is reduced to Loperamide and has the same antisecretory potency as Loperamide in jejunum and colon. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageReferences Lavrijsen, K., et al.: Drug Metab. Dispos., 23, 354 (1995), Hesselink, D., et al.: Clin. Pharmacol. Ther., 74, 245 (2003), Hooijberg, J., et al.: Biochem. Pharmacol., 67, 1541 (2004),

Chemische Eigenschaften

• Molekulargewicht: 493.04
• Formel: C₂₉H₃₃ClN₂O₃
• Farbe/Form: Off-White
• InChl: InChI=1S/C29H33ClN2O3/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32(35)20-17-28(34,18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3/t28-,32-
• InChI Key: InChIKey=KXVSBTJVTUVNPM-UHFFFAOYSA-N
• SMILES: CN(C)C(=O)C(CC[N+]1([O-])CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1