Lometrexol Hydrate

CAS: 106400-81-1

Ref. TR-L469465

Produktinformation

• Name: Lometrexol Hydrate
• Synonyme: N-[4-[2-[(6R)-2-Amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]-L-glutamic Acid Hydrate, LY 264618 Hydrate, Lometrexolum, Lometrexolum [INN-Latin], Unii-6P3Avy8A7Q, L-Glutamic acid, N-(4-(2-((6R)-2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)ethyl)benzoyl)-, L-Glutamic acid, N-(4-(2-(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)ethyl)benzoyl)-, (R)-, N-(4-{2-[(6R)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl}benzoyl)-L-glutamic acid

Beschreibung

Applications It is an antifolate which inhibits glycinamide ribonucleotide formyltransferase (GARFT), an enzyme essential for de novo purine synthesis. Lometrexol has activity against tumors which are refractory to other drugs, notably Methotrexate.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gibbs, D., et al.: Cancer Res., 65, 11721 (2005), Gangjee, A., et al.: J. Med. Chem., 48, 5329 (2005), Hilgenbrink, A., et al.: J. Pharm. Sci., 94, 2135 (2005),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 443.45 + x(18.02)
• Formel: C₂₁H₂₅N₅O₆·xH₂O
• Farbe/Form: Neat