2-Methoxy Canagliflozin

CAS: 1358581-37-9

Ref. TR-M261385

Produktinformation

• Name: 2-Methoxy Canagliflozin
• Synonyme: α-D-Glucopyranoside, methyl 1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]- (ACI), Methyl 1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-α-D-glucopyranoside (ACI)
• Marke: TRC
• Beschreibung: Applications 1-Methoxy Canagliflozin is an impurity in the synthesis of the drug Canagliflozin (C175190). Canagliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity.References Chao, E. et al.: Drug Fut., 36, 351 (2011); Sha, S. et al.: Diab. Obes. Metab., 13, 669 (2011); Kipnes, M.S.: Clin. Invest., 1, 145 (2011)

Chemische Eigenschaften

• Molekulargewicht: 474.542
• Formel: C₂₅H₂₇FO₆S
• Farbe/Form: Neat
• InChl: InChI=1S/C25H27FO6S/c1-14-3-6-17(25(31-2)24(30)23(29)22(28)20(13-27)32-25)11-16(14)12-19-9-10-21(33-19)15-4-7-18(26)8-5-15/h3-11,20,22-24,27-30H,12-13H2,1-2H3/t20-,22-,23+,24-,25+/m1/s1
• InChI Key: InChIKey=UKGXVMIGVXOCSH-HFBCXCLPSA-N
• SMILES: CO[C@@]1(c2ccc(C)c(Cc3ccc(-c4ccc(F)cc4)s3)c2)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O