6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylic Acid-d5

CAS: 851884-87-2

Ref. TR-M264217

Produktinformation

• Name: 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylic Acid-d5
• Synonyme: GKA 50-d5
• Marke: TRC

Beschreibung

Applications 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylic Acid-d5 is the labeled analogue of (M264215), which is one of the glucokinase activator derivatives. GKAs activate GK via binding to an allosteric site of the enzyme. They increase glucose-stimulated insulin secretion and decrease blood glucose levels. Also, glucokinase activator GKA50 is shown to be able to promote proliferation by increasing the cell volume and thus, preventing apoptosis in rat pancreatic insulinoma-1 beta cell.
References Wei, P., et al.: Diabetologia, 52, 2142 (2009); McGlasson, L., et al.: Mol. Cell. Endo., 342, 48, (2011);

Chemische Eigenschaften

• Molekulargewicht: 469.541
• Formel: C₂₆D₅H₂₃N₂O₆
• Farbe/Form: Neat
• InChl: InChI=1S/C26H28N2O6/c1-17(11-19-7-5-4-6-8-19)33-22-12-21(13-23(14-22)34-18(2)16-32-3)25(29)28-24-10-9-20(15-27-24)26(30)31/h4-10,12-15,17-18H,11,16H2,1-3H3,(H,30,31)(H,27,28,29)/t17-,18-/m0/s1/i4D,5D,6D,7D,8D
• InChI Key: InChIKey=OCBMECSFDVUYQN-SFJRSVAYSA-N
• SMILES: [2H]c1c([2H])c([2H])c(C[C@H](C)Oc2cc(O[C@@H](C)COC)cc(C(=O)Nc3ccc(C(=O)O)cn3)c2)c([2H])c1[2H]