7-Methyl Camptothecin

CAS: 78287-26-0

Ref. TR-M294565

Produktinformation

• Name: 7-Methyl Camptothecin
• Synonyme: (4S)-4-Ethyl-4-hydroxy-11-methyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione, 7-Methyl-20(S)-camptothecin, 7-Methylcamptothecin, 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4-hydroxy-11-methyl-, (S)-
• CAS: 78287-26-0

Beschreibung

Applications Camptothecin analog as DNA topoisomerase I inhibitors: a QSAR study. It may also be useful in the design and development of new camptothecin derivatives as DNA topoisomerase I (topo I) inhibitors. A poorly water soluble camptothecin analogue. Antitumor agent.
References Staker, B., et al.: J. Med. Chem., 48, 2336 (2005), Verma, R., et al.: Bioorg. Med. Chem., 13, 1059 (2005),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 362.38
• Formel: C₂₁H₁₈N₂O₄
• Farbe/Form: Yellow Solid
• InChl: InChI=1S/C21H18N2O4/c1-3-21(26)15-8-17-18-13(11(2)12-6-4-5-7-16(12)22-18)9-23(17)19(24)14(15)10-27-20(21)25/h4-8,26H,3,9-10H2,1-2H3/t21-/m0/s1
• InChI Key: InChIKey=XRCMSKXVQYEFOZ-NRFANRHFSA-N
• SMILES: CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2c-1nc1ccccc1c2C