6-Methyl-4-oxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide

CAS: 120279-88-1

Ref. TR-M330095

Produktinformation

• Name: 6-Methyl-4-oxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide
• Synonyme: 5,6-Dihydro-6-methyl-4-oxo-4H-thieno[2,3-b]thiopyran-2-sulfonamide, 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 5,6-dihydro-6-methyl-4-oxo-, 5,6-dihydro-6-methyl-4-oxo-4H-thieno-[2,3,b]thiopyran-2-sulfonamide

Beschreibung

Applications 6-Methyl-4-oxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide is an intermediate of Dorzolamide Hydrochloride (D535100), a carbonic anhydrase inhibitor. Antiglaucoma agent.
References Jiang, X., et. al.: Yingyong Huagong, 36, 1215 (2007); Lippa, E.A., et al.: Ophthalmology, 98, 308 (1991); Wang, R.-F., et al.: Arch. Ophthalmol., 109, 1297 (1991); Whikehart, D., et al.: J. Ocul. Pharmacol., 7, 195 (1991); Sjoquist, B., et al.: Drug Metab. Dispos., 26, 745 (1998)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 263.36
• Formel: C₈H₉NO₃S₃
• Farbe/Form: Neat
• InChl: InChI=1S/C8H9NO3S3/c1-4-2-6(10)5-3-7(15(9,11)12)14-8(5)13-4/h3-4H,2H2,1H3,(H2,9,11,12)
• InChI Key: InChIKey=QMNAQPMXDMLOLD-UHFFFAOYSA-N
• SMILES: CC1CC(=O)c2cc(S(N)(=O)=O)sc2S1