Mevastatin Hydroxy Acid Sodium Salt

CAS: 99782-89-5

Ref. TR-M340510

Produktinformation

• Name: Mevastatin Hydroxy Acid Sodium Salt
• Synonyme: (ßR,dR,1S,2S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-ß,d-dihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic Acid Sodium Salt (1:1), 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-ß,d-dihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, monosodium salt, [1S-[1a(ßS*,dS*),2a,8ß(R*),8aa]]-, 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-ß,d-dihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-, monosodium salt, (ßR,dR,1S,2S,8S,8aR)- (9CI), ML 236B sodium salt, Mevastatin Acid Sodium Salt

Beschreibung

Stability Hygroscopic
Applications An active carboxylate of Mevastatin (M340500). It is a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase with hypocholesterolemic activity. It has been shown to be effective in reducing cholesterol synthesis in vivo, and thereby in lowering cholesterol levels in blood.
References Endo, A. et al.: Atheroscler. Supp., 5, 39 (2004); Hosobuchi, M. et al.: J. Ferm. Bioeng., 76, 470 (1993);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 430.51
• Formel: C₂₃H₃₅O₆·Na
• Farbe/Form: Neat
• InChl: +1/p-1/t14-,15-,17+,18+,19-,20-,22-, InChI=1S/C23H36O6.Na/c1-4-14(2)23(28)29-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-17(24)12-18(25)13-21(26)27, /h6,8-9,14-15,17-20,22,24-25H,4-5,7,10-13H2,1-3H3,(H,26,27), /q, /m0./s1
• SMILES: CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)[O-])[C@H]21.[Na+]