Misonidazole

CAS: 13551-87-6

Ref. TR-M368700

Produktinformation

• Name: Misonidazole
• Synonyme: a-(Methoxymethyl)-2-nitro-1H-imidazole-1-ethanol, a-(Methoxymethyl)-2-nitroimidazole-1-ethanol, 1-(2-Hydroxy-3-methoxypropyl)-2-nitroimidazole, 1-(2-Nitro-1-imidazolyl)-3-methoxy-2-propanol, 2-Nitro-1H-imidazole-1-(3-methoxy-2-propanol), NSC 261037, Racemic Misonidazole, Ro 7-0582, SR 1354, SRI 1354, 1-Methoxy-3-(2-nitroimidazol-1-yl)propan-2-ol, Imidazole-1-ethanol, α-(methoxymethyl)-2-nitro-, Misonidazol, Nsc 261037, Racemic misonidazole, Sr 1354, Sri 1354, α-(Methoxymethyl)-2-nitro-1H-imidazole-1-ethanol, Imidazole-1-ethanol, .alpha.- (methoxymethyl)-2-nitro-, 1-Methoxy-3-(2-nitro-1H-imidazol-1-yl)propan-2-ol, 1H-Imidazole-1-ethanol, α-(methoxymethyl)-2-nitro-, 13551-87-6, .alpha.-(Methoxymethyl)-2-nitroimidazole-1-ethanol, 1-Methoxy-3-(2-nitro-1H-imidazol-1-yl)-2-propanol, 1H-imidazole-1-ethanol, alpha-(methoxymethyl)-2-nitro-, 1-Methoxy-3-(2-nitro-1-imidazolyl)-2-propanol, 1H-Imidazole-1-ethanol, .alpha.-(methoxymethyl)-2-nitro-

Beschreibung

Applications Misonidazole can be used as a potential hypoxic cancer cell radiosensitizer and DNA binding and nicking agent. The metabolites of misonidazole can themselves be cytotoxic or they can increase the chemosensitivity and radiosensitivity of the target cells
References Bonnet, M., et al.: Bioorg. Med. Chem., 22, 2123 (2014); Edwards, D.I.: Comprehensive Med. Chem., 2, 725 (1990); Murata, R., et al.: Radiother. Oncol., 87, 331 (2008); Brown, J.M. The mechanisms of cytotoxicity and chemosensitization by misonidazole and other nitroimidazoles. Int.J.Radiat.Oncol.Biol.Phys. 8(3-4), 675-682 (1982).

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 201.180
• Formel: C₇H₁₁N₃O₄
• Farbe/Form: Yellow Solid
• InChl: InChI=1S/C7H11N3O4/c1-14-5-6(11)4-9-3-2-8-7(9)10(12)13/h2-3,6,11H,4-5H2,1H3
• SMILES: COCC(O)Cn1ccnc1[N+](=O)[O-]