(E)-5-[2-(5-Nitro-2-furyl)vinyl]-2-furoic Acid

CAS: 18873-34-2

Ref. TR-N182660

Produktinformation

• Name: (E)-5-[2-(5-Nitro-2-furyl)vinyl]-2-furoic Acid

Beschreibung

Applications (E)-5-[2-(5-Nitro-2-furyl)vinyl]-2-furoic Acid is an intermediate in the synthesis of 5-[2-(5-Nitro-2-furanyl)ethenyl]-2-furancarboxylic Acid Methyl Ester (N493870), which is an inhibitor of G protein-coupled receptor kinase 2. 5-[2-(5-Nitro-2-furanyl)ethenyl]-2-furancarboxylic Acid Methyl Ester (N493870) was shown to normalize vascular endothelial function in type 2 diabetic mice by improving β-arrestin 2 translocation and ameliorating Akt/eNOS signal dysfunction.
References Taguchi, K., et al.: Endocrinol., 153, 2985 (2012);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 263.2
• Formel: C₁₂H₉NO₆
• Farbe/Form: Yellowish Green Solid
• SMILES: COC(=O)c1ccc(/C=C/c2ccc([N+](=O)[O-])o2)o1