β-Nicotinamide Mononucleotide

CAS: 1094-61-7

Ref. TR-N407765

Produktinformation

• Name: β-Nicotinamide Mononucleotide
• Synonyme: Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-ß-D-ribofuranosyl)-, inner salt, 3-Carbamoyl-1-ß-D-ribofuranosylpyridinium hydroxide, 5'-phosphate, inner salt (6CI,7CI), Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-ß-D-ribofuranosyl)-, hydroxide, inner salt, Pyridinium, 3-carbamoyl-1-ß-D-ribofuranosyl-, hydroxide, 5'-(dihydrogen phosphate), inner salt (8CI), NMN, NMN (mononucleotide), Nicotinamide mononucleotide, Nicotinamide ribonucleoside 5'-phosphate, Nicotinamide ribonucleotide, Nicotinamide ribotide, ß-D-NMN, ß-NMN, ß-Nicotinamide mononucleotide, 3-(Aminocarbonyl)-1-(5-O-phosphonato-beta-D-ribofuranosyl)pyridinium, 3-Carbamoyl-1-β-<span class="text-smallcaps">D</span>-ribofuranosylpyridinium hydroxide, 5′-phosphate, inner salt, 3-carbamoyl-1-(5-O-phosphonopentofuranosyl)pyridinium, 3-carbamoyl-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridinium, Nicotinamide ribonucleoside 5′-phosphate, Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-, inner salt, Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-, hydroxide, inner salt, Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-, inner salt, Pyridinium, 3-carbamoyl-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-, hydroxide, 5′-(dihydrogen phosphate), inner salt, coenzyme NMN, β-<span class="text-smallcaps">D</span>-NMN, β-NMN, β-Nicotinamide mononucleotide

Beschreibung

Stability Very Hygroscopic
Applications A product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.
References Yoshino, J. et al.: Cell Metab., 14, 528 (2011); Caton, P.W. et al.: Diabetologia, 54, 3083 (2011); Formentini, L. et al.: BIochem. Pharmacol., 77, 1612 (2009);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 334.22
• Formel: C₁₁H₁₅N₂O₈P
• Farbe/Form: White
• InChl: InChI=1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/m1/s1
• SMILES: N=C(O)c1ccc[n+]([C@@H]2O[C@H](COP(=O)([O-])O)[C@@H](O)[C@H]2O)c1