Nitisinone

CAS: 104206-65-7

Ref. TR-N490135

Produktinformation

• Name: Nitisinone
• Synonyme: 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione, 1,3-Cyclohexanedione, 2-[2-nitro-4-(trifluoromethyl)benzoyl]-, 2-[2-Nitro-4-(Trifluoromethyl)Benzoyl]Cyclohexane-1,3-Dione, 2-[2-Nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione, Nitisone, Nityr, Orfadin, Sc 0735

Beschreibung

Applications Nitisinone is a herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. It is used in treatment of inherited tyrosinemia type I.
References Lindstedt, S., et al.: Lancet, 340, 813 (1992), Ellis, M.K., et al.: Toxicol. Appl. Pharmacol., 133, 12 (1995), Lock, E.A., et al.: J. Inherited Metab. Dis., 21, 498 (1998),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 329.23
• Formel: C₁₄H₁₀F₃NO₅
• Farbe/Form: Neat
• InChl: InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2
• SMILES: O=C1CCCC(=O)C1C(=O)c1ccc(C(F)(F)F)cc1[N+](=O)[O-]