8-Nitroguanosine

CAS: 337536-53-5

Ref. TR-N496050

Produktinformation

• Name: 8-Nitroguanosine
• Synonyme: 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-nitro-1H-purin-6-one

Beschreibung

Applications A highly reactive redox-active nucleic acid derivative that is formed in cellular RNA as biomarker of exposure to reactive nitrogen species. Recent studies suggest that it might contribute to the pathogenesis of inflammation-associated carcinogenesis.
References Sawa, T. et al.: Biochem. Biophys. Res. Comm., 311, 300 (2003); Masuda, M. et al.: Chem.-Biol. Inter., 139, 187 (2002); Kaneko, K. et al.: Cancer Lett., 262, 239 (2008);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 328.24
• Formel: C₁₀H₁₂N₆O₇
• Farbe/Form: Neat
• InChl: InChI=1S/C10H12N6O7/c11-9-13-6-3(7(20)14-9)12-10(16(21)22)15(6)8-5(19)4(18)2(1-17)23-8/h2,4-5,8,17-19H,1H2,(H3,11,13,14,20)/t2-,4-,5-,8-/m1/s1
• SMILES: Nc1nc(=O)c2nc([N+](=O)[O-])n([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2[nH]1