2-[(3-Nitrophenyl)methylene]-3-oxo-butanoic Acid 2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl Ester Hydrochloride

CAS: 929212-20-4

Ref. TR-N504405

Produktinformation

• Name: 2-[(3-Nitrophenyl)methylene]-3-oxo-butanoic Acid 2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl Ester Hydrochloride
• Synonyme: (E)-1-((3,3-Diphenylpropyl)(methyl)amino)-2-methylpropan-2-yl 2-(3-Nitrobenzylidene)-3-oxobutanoate Hydrochloride

Beschreibung

Applications 2-[(3-Nitrophenyl)methylene]-3-oxo-butanoic Acid 2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl Ester Hydrochloride is an intermediate in synthesizing 5-Ethyl-demethyl Lercanidipine (E913200), which is an impurity of Lercanidipine (L179000), a dihydropyridine calcium channel blocker.
References Bianchi, G., et al.: Pharmacol. Res., 21, 193 (1989); Rimoldi, E., et al.: Acta Therap., 200, 23 (1994); Argekar, A., et al.: J. Pharm. Biomed. Anal., 21, 1137 (2000);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 514.61+(36.46)
• Formel: C₃₁H₃₄N₂O₅·HCl
• Farbe/Form: Neat
• InChl: InChI=1S/C31H34N2O5.ClH/c1-23(34)29(21-24-12-11-17-27(20-24)33(36)37)30(35)38-31(2,3)22-32(4)19-18-28(25-13-7-5-8-14-25)26-15-9-6-10-16-26;/h5-17,20-21,28H,18-19,22H2,1-4H3;1H/b29-21+
• InChI Key: InChIKey=CGKZRAHLZUMTHC-ORVJAXSGSA-N
• SMILES: CC(=O)/C(=C\c1cccc([N+](=O)[O-])c1)C(=O)OC(C)(C)CN(C)CCC(c1ccccc1)c1ccccc1.Cl