4-Nitrothalidomide

CAS: 19171-18-7

Ref. TR-N565525

Produktinformation

• Name: 4-Nitrothalidomide
• Synonyme: 2-(2,6-Dioxo-3-piperidinyl)-4-nitro-1H-isoindole-1,3(2H)-dione, 2-(2,6-Dioxopiperidin-3-yl)-4-nitro-isoindole-1,3-dione, 4-Nitro-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione, 1H-isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-nitro-, 2-(2,6-Dioxopiperidin-3-Yl)-4-Nitroisoindoline-1,3-Dione, Ec1-078, Phthalimide, N-(2,6-dioxo-3-piperidyl)-3-nitro-

Beschreibung

Applications 4-Nitrothalidomide is a compound involved in the preparation of Pomalidomide (P688200), a thalidomide derivative and potent inhibitor of TNF-α production.
References Huang, D., et al.: Syn. Comm., 46, 1343-1348 (2016); Ruchelman, A. et al.: Bioorg. Med. Chem. Lett., 23, 360 (2013); Latif, T. et al.: Exp. Hematol. Oncol., 1, 27 (2012); Man, H. et al.: Bioorg. Med. Chem. Lett., 13, 3415 (2003); Muller, G. et al.: Bioorg. Med. Chem. Lett., 9, 1625 (1999)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 303.23
• Formel: C₁₃H₉N₃O₆
• Farbe/Form: Neat
• SMILES: O=C1CCC(N2C(=O)c3cccc([N+](=O)[O-])c3C2=O)C(=O)N1