NS-2028

CAS: 204326-43-2

Ref. TR-N900200

Produktinformation

• Name: NS-2028
• Synonyme: 8-bromo-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one, 1H,4H-[1,2,4]Oxadiazolo[3,4-c][1,4]benzoxazin-1-one, 8-bromo-, 4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)ben(b)(1,4)oxazin-1-one, 8-Bromo-1H,4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one, Ns 2028, 8-Bromo-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one

Beschreibung

Applications NS-2028 potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). NS-2028 blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA. NS-2028 inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).
References Olesen, et al.: Br. J. Pharmacol., 123, 299 (1998), von Wantoch Rekowski, et al.: Bioorg. Med. Chem. 18, 1288 (2010),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 269.05
• Formel: C₉H₅BrN₂O₃
• Farbe/Form: Neat
• InChl: InChI=1S/C9H5BrN2O3/c10-5-1-2-7-6(3-5)12-8(4-14-7)11-15-9(12)13/h1-3H,4H2
• InChI Key: InChIKey=MUDRLQRJCGJJTB-UHFFFAOYSA-N
• SMILES: O=c1onc2n1-c1cc(Br)ccc1OC2