Olopatadine Isopropyl Ester

CAS: 1206456-44-1

Ref. TR-O575025

Produktinformation

• Name: Olopatadine Isopropyl Ester
• Synonyme: (11Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid 1-methylethyl ester

Beschreibung

Applications Olopatadine Isopropyl Ester is an intermediate used to prepare Olopatadine (O575000, HCl salt) via Wittig reaction. Olopatadine is a dual acting histamine H1-receptor antagonist and mast cell stabilizer.
References Kamei, C., et al.: Arzneim.-Forsch., 45, 1005 (1995); Sharif, N.A., et al.: J. Pharmacol. Exp. Ther., 278, 1252 (1996); Abelson, M.B., et al.: Am. J. Ophthalmol., 125, 797 (1998); Silva, G., et al.: Eur. Pat. Appl., EP 2145882 A1 20100120 (2010)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 379.49
• Formel: C₂₄H₂₉NO₃
• Farbe/Form: Colourless To Light Yellow
• InChl: InChI=1S/C24H29NO3/c1-17(2)28-24(26)15-18-11-12-23-22(14-18)21(10-7-13-25(3)4)20-9-6-5-8-19(20)16-27-23/h5-6,8-12,14,17H,7,13,15-16H2,1-4H3/b21-10-
• InChI Key: InChIKey=AEZOYXJGZPHCRI-FBHDLOMBSA-N
• SMILES: CC(C)OC(=O)Cc1ccc2c(c1)/C(=C\CCN(C)C)c1ccccc1CO2