8-Oxo-Benzylguanine

CAS: 158754-46-2

Ref. TR-O847390

Produktinformation

• Name: 8-Oxo-Benzylguanine
• Synonyme: 2-Amino-7,9-dihydro-6-(phenylmethoxy)-8H-purin-8-one, NU 6043

Beschreibung

Applications 8-Oxo-Benzylguanine is a derivative of O-Benzylguanine, an reversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. O-Benzylguanine is known to assists in the protection against carcinogenic and therapeutic alkylating agents.
References Dolan, M.E., et al.: Proc. Natl. Acad. Sci. USA, 87, 5356 (1990), Goodtzova, K., et al.: Biochemistry, 33, 385 (1994), Elder, R.H., et al.: Biochem. J., 298, 231 (1994)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 257.25
• Formel: C₁₂H₁₁N₅O₂
• Farbe/Form: Neat
• InChl: InChI=1S/C12H11N5O2/c13-11-15-9-8(14-12(18)16-9)10(17-11)19-6-7-4-2-1-3-5-7/h1-5H,6H2,(H4,13,14,15,16,17,18)
• InChI Key: InChIKey=VPMJBCMAJPZWIC-UHFFFAOYSA-N
• SMILES: Nc1nc(OCc2ccccc2)c2[nH]c(=O)[nH]c2n1