2-Oxo-2-(1-phenyl-1H-pyrazol-4-yl)acetic Acid

CAS: 1152495-65-2

Ref. TR-O858630

Produktinformation

• Name: 2-Oxo-2-(1-phenyl-1H-pyrazol-4-yl)acetic Acid
• Synonyme: 2-oxo-2-(1-phenylpyrazol-4-yl)acetic acid

Beschreibung

Applications 2-Oxo-2-(1-phenyl-1H-pyrazol-4-yl)acetic Acid is a derivative of N-Phenylpyrazole, a reactant in the synthesis of candesartan cilexetil(C175580), an ester prodrug; hydrolized in vivo to the active carboxylic acid. Used in treatment of congestive heart failure. Antihypertensive.
References Seki, M. et. al: ACS Catalysis, 4, 4047 (2014); Shibouta, Y., et al.: J. Pharmacol. Exp. Ther., 266, 114 (1993; Ogihara, T., et al.: Clin. Ther., 16, 74 (1994)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 216.193
• Formel: C₁₁H₈N₂O₃
• Farbe/Form: Neat
• InChl: InChI=1S/C11H8N2O3/c14-10(11(15)16)8-6-12-13(7-8)9-4-2-1-3-5-9/h1-7H,(H,15,16)
• InChI Key: InChIKey=PIXYCNJJZPLCTN-UHFFFAOYSA-N
• SMILES: O=C(O)C(=O)c1cnn(-c2ccccc2)c1