1-Oxo Fexofenadine Methyl Ester

CAS: 154477-55-1

Ref. TR-O870040

Produktinformation

• Name: 1-Oxo Fexofenadine Methyl Ester
• Synonyme: 4-[4-[4-(Hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]-alpha,alpha-dimethylbenzeneacetic Acid Methyl Ester, 2-[4-[4-[4-(Hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]phenyl]-2,2-dimethylacetic Acid Methyl Ester, Methyl 4-[4-[4-(Hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]-alpha,alpha-dimethylphenylacetate
• Marke: TRC

Beschreibung

Applications 1-Oxo Fexofenadine Methyl Ester, is an intermediate in the preparation of Fexofenadine (F322470). It can also be used for the synthesis of an oxidation metabolite of Terfenadine (T114500),a H1-receptor antagonist.
References Garteiz, D.A., et al.: Arzneim.-Forsch., 32, 1185 (1982), Rampe, D., et al.: Mol. Pharmacol., 44, 1240 (1993), Obradovic, T., et al.: Pharm. Res., 24, 318 (2007); Kawai, S., et al.: J. Org. Chem., 59, 2620 (1994);

Chemische Eigenschaften

• Molekulargewicht: 513.67
• Formel: C₃₃H₃₉NO₄
• Farbe/Form: Neat
• InChl: InChI=1S/C33H39NO4/c1-32(2,31(36)38-3)26-18-16-25(17-19-26)30(35)15-10-22-34-23-20-29(21-24-34)33(37,27-11-6-4-7-12-27)28-13-8-5-9-14-28/h4-9,11-14,16-19,29,37H,10,15,20-24H2,1-3H3
• InChI Key: InChIKey=PGQMZSGBFIPEKX-UHFFFAOYSA-N
• SMILES: COC(=O)C(C)(C)c1ccc(C(=O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1