Palovarotene

CAS: 410528-02-8

Ref. TR-P165900

Produktinformation

• Name: Palovarotene
• Synonyme: 4-[(E)-2-[5,5,8,8-tetramethyl-3-(pyrazol-1-ylmethyl)-6,7-dihydronaphthalen-2-yl]ethenyl]benzoic acid, 4-[(1E)-2-[5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-2-naphthalenyl]ethenyl]benzoic acid, 4-{(1E)-2-[5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-5,6,7,8-tetrahydronaphthalen-2-yl]ethenyl}benzoicacid, Benzoic acid, 4-[(1E)-2-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-2-naphthalenyl]ethenyl]-, Clm 001, Ipn 60120, R 667, Ro 3300074, Sohonos
• CAS: 410528-02-8

Beschreibung

Applications Palovarotene, is a highly selective retinoic acid receptor gamma (RAR-γ) agonist that is under investigation as a potential treatment for emphysema.
References Hind, M., et al.: Curr. Opinion Invest. Drugs, 10(11), 1243 (2009); Stolk, J., et al.: Therap. advances Respi. dise., 4, 319 (2010);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 414.54
• Formel: C₂₇H₃₀N₂O₂
• Farbe/Form: Neat
• InChl: InChI=1S/C27H30N2O2/c1-26(2)12-13-27(3,4)24-17-22(18-29-15-5-14-28-29)21(16-23(24)26)11-8-19-6-9-20(10-7-19)25(30)31/h5-11,14-17H,12-13,18H2,1-4H3,(H,30,31)/b11-8+
• InChI Key: InChIKey=YTFHCXIPDIHOIA-DHZHZOJOSA-N
• SMILES: CC1(C)CCC(C)(C)c2cc(Cn3cccn3)c(/C=C/c3ccc(C(=O)O)cc3)cc21