Produktinformation
- Patulin (6CI)
- 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one
- Acetic acid
- (2,4-dihydroxy-2H-pyran-3(6H)-ylidene)-
- 3,4-lactone
- Clairformin
- Clavacin
- Clavatin
- Claviformin
- DL-Patulin
- Mehr Synonyme anzeigen
- Expansin
- Expansin (antibiotic)
- Expansine
- Gigantin
- Leucopin
- Mycoin
- Mycoin C
- Mycoin C3
- NSC 32951
- NSC 8120
- Patuline
- Penicidin
- Terinin
- 4,6-Dihydro-4-hydroxy-2H-furo[3,2-c]pyran-2-on
- 4,6-dihidro-4-hidroxi-2H-furo[3,2-c]piran-2-ona
- 4,6-dihydro-4-hydroxy-2H-furo[3,2-c]pyran-2-one
- 4,6-dihydro-4-hydroxy-2H-furo[3,2-c]pyranne-2-one
- <span class="text-smallcaps">DL</span>-Patulin
- Acetic acid, (2,4-dihydroxy-2H-pyran-3(6H)-ylidene)-, 3,4-lactone
- Mycoin C<sub>3</sub>
- Nsc 32951
- Nsc 8120
- CCRIS 4940
- Tercinin
- Claviform
- Mycoine C3
- HSDB 3522
- (2,4-Dihydroxy-2H-pyran-3(6H)-ylidene)acetic acid, 3,4-lactone
- 2H-Pyran-delta(sup 3(6H),alpha)-acetic acid, 2,4-dihydroxy-, 3,4-lactone
- (4R)-4-hydroxy-4H-furo[3,2-c]pyran-2(6H)-one
- 5-18-03-00005 (Beilstein Handbook Reference)
- 4H-Furo[3,2-c]pyran-2(6H)-one, 4-hydroxy-
- Penatin
- 4H-Furo(3,2-c)pyran-2(6H)-one, 4-hydroxy-
- BRN 0149675
- 2,4-Dihydroxy-2H-pyran-delta-3(6H),alpha-acetic acid-3,4-lactone
- (4S)-4-hydroxy-4H-furo[3,2-c]pyran-2(6H)-one
- 4H-Furo(3,3-c)pyran-2(6H)-one, 4-hydroxy-
- (2,4-Dihydroxy-2H-pyran-3(6H)-ylidene)acetic acid-3,4-lactone
- Mycosin
Stability Hygroscopic
Applications Patulin (PAT), a mycotoxin produced by certain species of Penicillium, Aspergillus, and Byssochlamys, is mainly found in ripe apple and apple products. Patulin-induced genotoxicity and modulation of glutathione in Hep G2 cells. Patulin is an antibiotic. Patulin-induced nephropathy and gastrointestinal tract malfunction have been demonstrated in several animal models. The oral LD50 value of patulin ranges between 29 and 55 mg/kg body weight in rodents and 170 mg/kg body weight in poultry. The World Health Organization considers patulin cytotoxic and established a safety level of patulin in apple juice at 50 μM. At 100-200 μM, patulin can directly increase intracellular oxidative stress in HEK293 and HL-60 cells. In 1944, this compound was tested in a clinical trial for potential antibiotic
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Scott, P., et al.: J. Agric. Food Chem., 20, 450 (1972), Aden, D., et al.: Nature, 282, 615 (1979), Surralles, J., et al.: Mutat. Res., 341, 169 (1995), Alves, I., et al.: Mutagenesis, 15, 229 (2000), Liu, B., et al.: Toxicol. Appl. Pharmacol., 191, 255 (2003), Puel, O., Galtier, P., and Oswald, I.P. Biosynthesis and toxicological effects of patulin. Toxins 2(4) 613-631 (2010). Liu, B., Wu, T., Yu, F., et al. Induction of oxidative stress response by the mycotoxin patulin in mammalian cells. Toxicol Sci 95(2) 340-347 (2007). Chalmers, I., and Clarke, M. Commentary: The 1994 patulin trial: The first properly controlled multicentre trial conducted under the aegis of the British Medical Research Council. Int J Epidemiol 32 253-260 (2004).
Chemische Eigenschaften
Technische Anfrage zu: TR-P206500 Patulin
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