Pemetrexed-5-methyl Ester

CAS: 1265908-64-2

Ref. TR-P219545

Produktinformation

• Name: Pemetrexed-5-methyl Ester
• Synonyme: L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, 5-methyl ester, (2S)-2-[[4-[2-(2-Amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]-5-methoxy-5-oxo-pentanoic acid, N-[4-[2-(2-Amino
• Marke: TRC
• Beschreibung: Applications Pemetrexed-5-methyl Ester is an impurity of Pemetrexed Disodium Heptahydrate (P219550), an inhibitor of thymidylate synthase (and folate dependent enzymes) and a chemotherapy drug for the treatment of pleural mesothelioma and non-small cell lung cancer.References Vogelzang, N.J., et al.: J. Clin. Oncol., 21,2636 (2003); Paz-Ares, L., et al.: Lancet. Oncol., 13, 247 (2012)P219545

Chemische Eigenschaften

• Molekulargewicht: 441.437
• Formel: C₂₁H₂₃N₅O₆
• Farbe/Form: Neat
• InChl: InChI=1S/C21H23N5O6/c1-32-15(27)9-8-14(20(30)31)24-18(28)12-5-2-11(3-6-12)4-7-13-10-23-17-16(13)19(29)26-21(22)25-17/h2-3,5-6,10,14H,4,7-9H2,1H3,(H,24,28)(H,30,31)(H4,22,23,25,26,29)/t14-/m0/s1
• InChI Key: InChIKey=KHRSEJRFFOKXIA-AWEZNQCLSA-N
• SMILES: COC(=O)CC[C@H](NC(=O)c1ccc(CCc2c[nH]c3[nH]c(N)nc(=O)c23)cc1)C(=O)O