(4S)-4-Hydroxy Pravastatin Lactone

Ref. TR-P702120

Produktinformation

• Name: (4S)-4-Hydroxy Pravastatin Lactone
• Synonyme: (2S)-(1S,3S,7S,8S,8aR)-3-Hydroxy-8-(2-((4S)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoate
• Marke: TRC
• Beschreibung: Applications (4S)-4-Hydroxy Pravastatin Lactone is an intermediate in the synthesis of Pravastatin 6'-Ketone Sodium Salt (P702050), which is an impurity of Pravastatin Sodium (P702000), which is a competitive inhibitor of HMG-CoA reductase. It can be used as a drug to for lowering cholesterol and preventing cardiovascular disease.References Serizawa, N., et al.: J. Antibiot., 36, 604 (1983), Yoshino, G., et al.: Lancet, 2, 740 (1986), White, H.D, et al.: N. Engl. J. Med., 343, 317 (2000)

Chemische Eigenschaften

• Molekulargewicht: 406.512
• Formel: C₂₃H₃₄O₆
• Farbe/Form: Neat
• InChl: InChI=1S/C23H34O6/c1-4-13(2)23(27)29-20-11-16(24)9-15-6-5-14(3)19(22(15)20)8-7-18-10-17(25)12-21(26)28-18/h5-6,9,13-14,16-20,22,24-25H,4,7-8,10-12H2,1-3H3/t13-,14-,16+,17-,18?,19-,20-,22-/m0/s1
• InChI Key: InChIKey=OQARDMYXSOFTLN-URZBBATNSA-N
• SMILES: CC[C@H](C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CCC3C[C@H](O)CC(=O)O3)[C@H]21