Pregnenolone Carbonitrile

CAS: 1434-54-4

Ref. TR-P712240

Produktinformation

• Name: Pregnenolone Carbonitrile
• Synonyme: 3β-Hydroxy-20-oxo-pregn-5-ene-16α-carbonitrile, 16α-Cyanopregnenolone, 3β-Hydroxy-20-oxo-5-pregnen-16α-carbonitrile, 3β-Hydroxy-20-oxopregn-5-ene-16α-carbonitrile, 5-Pregnen-3β-ol-20-one-16α-carbonitrile, PCN, Pregn-5-ene-3β-ol-20-oxo-16α-carbonitrile, Pregnenolone 16α-Carbonitrile, SC 4674, (3S,8S,9S,10R,13S,14S,16R,17S)-17-Acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-16-carbonitrile
• Marke: TRC

Beschreibung

Applications Pregnenolone Carbonitrile is a glucocorticoid receptor antagonist that induces the expression of the CYP3A family of steroid hydroxylases and modulates sterol and bile acid biosynthesis in vivo. Pregnenolone Carbonitrile is an an activator of rat pregnane X receptor (PXR).
References Kliewer, S.A., et. al.: Cell, 92, 73 (1998); Savas, U., et. al.: Drug Metab. Dispos., 28, 529 (2000)

Chemische Eigenschaften

• Molekulargewicht: 341.49
• Formel: C₂₂H₃₁NO₂
• Farbe/Form: Neat
• InChl: InChI=1S/C22H31NO2/c1-13(24)20-14(12-23)10-19-17-5-4-15-11-16(25)6-8-21(15,2)18(17)7-9-22(19,20)3/h4,14,16-20,25H,5-11H2,1-3H3/t14-,16-,17+,18-,19-,20-,21-,22-/m0/s1
• InChI Key: InChIKey=HMMPCBAWTWYFLR-UHFFFAOYSA-N
• SMILES: c1ccc(Nc2ccccn2)nc1