2-Pyrazinecarbonyl Chloride

CAS: 19847-10-0

Ref. TR-P840805

Produktinformation

• Name: 2-Pyrazinecarbonyl Chloride
• Synonyme: pyrazine-2-carbonyl chloride, Pyrazine-2-carbonyl chloride, Pyrazine-2-carboxylic acid chloride, Pyrazinecarbonyl chloride, Pyrazinoic acid chloride, Pyrazinoyl chloride

Beschreibung

Applications 2-Pyrazinecarbonyl Chloride is an intermediate used in the synthesis of (S)-N-[1-(3-Hydroxy-3-methylbutanamido)-1-oxo-3-phenylpropan-2yl]pyrazine-2-carboxamide (H805105), which is an impurity of bortezomib (B675700), which is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 142.543
• Formel: C₅H₃ClN₂O
• Farbe/Form: Neat
• InChl: InChI=1S/C5H3ClN2O/c6-5(9)4-3-7-1-2-8-4/h1-3H
• InChI Key: InChIKey=TXJKATOSKLUITR-UHFFFAOYSA-N
• SMILES: O=C(Cl)c1cnccn1