Acetamide Baricitinib Impurity

CAS: 2271228-51-2

Ref. TR-P852225

Produktinformation

• Name: Acetamide Baricitinib Impurity
• Synonyme: 1-​(Ethylsulfonyl)​-​3-​[4-​(7H-​pyrrolo[2,​3-​d]​pyrimidin-​4-​yl)​-​1H-​pyrazol-​1-​yl]​-3-azetidineacetamide, 2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetamide

Beschreibung

Applications 2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetamide is an impurity of Baricitinib (B118690), which is a JAK1 and JAK2 inhibitor and has been studied as a promising treatment for rheumatoid arthritis.
References Dasari, S., et. al.: Russ. J. Org., 55, 1569 (2019);Zhang, F., et. al.: Faming Zhuanli Shenqing 11pp. Patent (2018), CN 108976233 A 20181211;Greenwald, L., et. al.: Int. J. Clin. Rheumatol., 6, 401 (2011); Fridman, J., et. al.: J. Immunol., 184, 5298 (2010);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 389.43
• Formel: C₁₆H₁₉N₇O₃S
• Farbe/Form: Off-White To Light Yellow
• InChl: InChI=1S/C16H19N7O3S/c1-2-27(25,26)22-8-16(9-22,5-13(17)24)23-7-11(6-21-23)14-12-3-4-18-15(12)20-10-19-14/h3-4,6-7,10H,2,5,8-9H2,1H3,(H2,17,24)(H,18,19,20)
• InChI Key: InChIKey=GKBJBCCNXISYKV-UHFFFAOYSA-N
• SMILES: CCS(=O)(=O)N1CC(CC(N)=O)(n2cc(-c3ncnc4[nH]ccc34)cn2)C1