Raltitrexed

CAS: 112887-68-0

Ref. TR-R100500

Produktinformation

• Name: Raltitrexed
• Synonyme: N-[[5-[[(3,4-Dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic Acid, L-Glutamic acid, N-[[5-[[(1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]- (9CI), D 1694, ICI-D 1694, N-[[5-[[(3,4-Dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic acid, TDX, Tomudex, ZD 1694
• Marke: TRC

Beschreibung

Applications Folate-based inhibitor of thymidylate synthase; rapidly and extensively metabolized to its more potent polyglutamate derivatives. Antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Jodrell, D.I., et al.: Cancer Chemother. Pharmacol., 28, 331 (1991), Jackman, A.L., et al.: Eur. J. Cancer, 31A, 1277 (1995)

Chemische Eigenschaften

• Molekulargewicht: 458.49
• Formel: C₂₁H₂₂N₄O₆S
• Farbe/Form: Neat
• InChl: InChI=1S/C21H22N4O6S/c1-11-22-14-4-3-12(9-13(14)19(28)23-11)10-25(2)17-7-6-16(32-17)20(29)24-15(21(30)31)5-8-18(26)27/h3-4,6-7,9,15H,5,8,10H2,1-2H3,(H,24,29)(H,26,27)(H,30,31)(H,22,23,28)/t15-/m0/s1
• InChI Key: InChIKey=IVTVGDXNLFLDRM-HNNXBMFYSA-N
• SMILES: Cc1nc2ccc(CN(C)c3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)cc2c(=O)[nH]1