Ranimustine

CAS: 58994-96-0

Ref. TR-R120030

Produktinformation

• Name: Ranimustine
• Synonyme: a-D-Glucopyranoside, methyl 6-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-6-deoxy-, Methyl 6-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-6-deoxy-a-D-glucopyranoside, Cymerin, Cymerine, MCNU, NSC 270516, 3-(Methyl-a-D-glucopyranos-6-yl)-1-(2-chloroethyl)-1-nitrosourea, 58994-96-0, Methyl 6-[[[(2-Chloroethyl)nitrosoamino]carbonyl]amino]-6-deoxy-a-D-glucopyranoside, Methyl 6-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-6-deoxy-α-<span class="text-smallcaps">D</span>-glucopyranoside, Methyl 6-{[(2-Chloroethyl)(Nitroso)Carbamoyl]Amino}-6-Deoxyhexopyranoside, Methyl 6-{[(2-chloroethyl)(nitroso)carbamoyl]amino}-6-deoxy-alpha-D-glucopyranoside, Methyl N-Carbamyl-N'-(2-chloroethyl)-N'-nitroso-6-amino-6-deoxy-a-D-glucopyranoside, Ranomustine, α-<span class="text-smallcaps">D</span>-Glucopyranoside, methyl 6-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-6-deoxy-
• CAS: 58994-96-0

Beschreibung

Applications A nitrosourea alkylating agent approved in Japan for the treatment of chronic myelogenous leukemia and polycythemia vera. It can be used in biological study of synthesis of anti-EGFR antibody-drug conjugates. It can also be used in therapeutic use and biological study of BCMA (B-Cell Maturation Antigen) antigen binding proteins.
References Choi, H., et al.: PCT Int. Appl., WO 2017051254 A1 20170330 (2017);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 327.72
• Formel: C₁₀H₁₈ClN₃O₇
• Farbe/Form: Off White Powder
• InChl: InChI=1S/C10H18ClN3O7/c1-20-9-8(17)7(16)6(15)5(21-9)4-12-10(18)14(13-19)3-2-11/h5-9,15-17H,2-4H2,1H3,(H,12,18)/t5-,6-,7+,8-,9+/m1/s1
• InChI Key: InChIKey=AHHFEZNOXOZZQA-ZEBDFXRSSA-N
• SMILES: CO[C@H]1O[C@H](CNC(=O)N(CCCl)N=O)[C@@H](O)[C@H](O)[C@H]1O