Roxadustat Methyl Ester

CAS: 1421312-36-8

Ref. TR-R410460

Produktinformation

• Name: Roxadustat Methyl Ester
• Synonyme: methyl 2-[(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetate

Beschreibung

Applications Roxadustat Methyl Ester is used in the preparation of Roxadustat.Roxadustat (H948180) is a hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor used to increase white blood cell levels in blood and hematopoietic progenitor cells in bone marrow.It is used for treatment of anemia in patient with chronic kidney disease.
References Wang, Z.: Faming Zhuanli Shenqing. 7 pp. (2018)Provenzano, R., et al.: J. Clin. Pharmacol. 60, 1432 (2020)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 366.367
• Formel: C₂₀H₁₈N₂O₅
• Farbe/Form: Neat
• InChl: InChI=1S/C20H18N2O5/c1-12-16-10-14(27-13-6-4-3-5-7-13)8-9-15(16)19(24)18(22-12)20(25)21-11-17(23)26-2/h3-10,24H,11H2,1-2H3,(H,21,25)
• InChI Key: InChIKey=QSGJZCCNTOCDRI-UHFFFAOYSA-N
• SMILES: COC(=O)CNC(=O)c1nc(C)c2cc(Oc3ccccc3)ccc2c1O