(R)-Ruxolitinib (>90%)

CAS: 941678-49-5

Ref. TR-R702000

Produktinformation

• Name: (R)-Ruxolitinib (>90%)
• Synonyme: (ßR)-ß-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile, (3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile, (ßR)-ß-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile, INC 424, INCB 018424, Ruxolitinib, (Betar)-Beta-Cyclopentyl-4-(7H-Pyrrolo(2,3-D)Pyrimidin-4-Yl)-1H-Pyrazole-1-Propanenitrile, (R)-3-[4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-cyclopentylpropanenitrile, (βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile, 1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βR)-, Inc 424, Incb-018424, R-Incb018424, R-Ruxolitinib, Ruxolitinib (INCB 018424), Ruxolitinib phosphate salt

Beschreibung

Applications Ruxolitinib is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis. Potent JAK2 inhibitor.
References Shilling, A.D. et al.: Drug Metab. Disp., 38, 2023 (2010); Mesa, R.A.: IDrugs, 13, 394 (2010); Campas-Moya, C.: Drugs Fut., 35, 457 (2010);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 306.36
• Formel: C₁₇H₁₈N₆
• Reinheit: >90%
• Farbe/Form: White To Beige
• InChl: InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1
• SMILES: N#CC[C@H](C1CCCC1)n1cc(-c2nc[nH]c3nccc2-3)cn1