Sacubitril Calcium

CAS: 1369773-39-6

Ref. TR-S080900

Produktinformation

• Name: Sacubitril Calcium
• Synonyme: [S-(R*,S*)]-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-,[1,1'-biphenyl]-4-pentanoic Acid Ethyl Ester Calcium salt, (2R,4S)-4-[(3-Carboxy-1-oxopropyl)amino]-4-[(p-phenylphenyl)methyl]-2-methylbutanoic acid ethyl ester Calcium salt, (2R,4S)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester Calcium salt, AHU 377 Calcium salt
• Marke: TRC
• Beschreibung: Applications Sacubitril is an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.References McMurray, J., et al.: N. Eng. J. Med., 371 (2014)

Chemische Eigenschaften

• Molekulargewicht: 430.52
• Formel: C₂₄H₂₈NOCa₂
• Farbe/Form: Neat
• InChl: InChI=1S/2C24H29NO5.Ca/c2*1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19;/h2*4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28);/q;;+2/p-2/t2*17-,21+;/m11./s1
• InChI Key: InChIKey=PYNXFZCZUAOOQC-OQHSHRKDSA-M
• SMILES: CCOC(=O)[C@H](C)CC(Cc1ccc(-c2ccccc2)cc1)NC(=O)CCC(=O)[O-]