Saxagliptin Hydrochloride

CAS: 709031-78-7

Ref. TR-S143753

Produktinformation

• Name: Saxagliptin Hydrochloride
• Synonyme: 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, hydrochloride (1:1), (1S,3S,5S)-, 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, monohydrochloride, (1S,3S,5S)- (9CI), Saxagliptin HCL salt, Saxagliptin HCL

Beschreibung

Applications Saxagliptin is a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration and has a pharmacokinetic profile compatible with once daily dosing.
References Feng, J., et al.: J. Med. Chem., 50, 2297 (2007), Rosenstock, J., et al.: Diabetes Obes. Metab., 10, 376 (2008), Thomas, L., et al.: J. Pharmacol. Exp. Ther., 325, 175 (2008),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 351.87
• Formel: C₁₈H₂₅N₃O₂·ClH
• Farbe/Form: Neat
• InChl: InChI=1S/C18H25N3O2.ClH/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17, /m1./s1, /h10-15,23H,1-7,9,20H2, 1H/t10?,11?,12-,13+,14+,15-,17?,18?
• InChI Key: InChIKey=OTTYFDRFBJPGRW-ONEGZZNKSA-N
• SMILES: CC/C=C/C(=O)Cl