Sitagliptin-d4 Phosphate

CAS: 1432063-88-1

Ref. TR-S491002

Produktinformation

• Name: Sitagliptin-d4 Phosphate
• Synonyme: (2R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-5,5,6,6-tetradeuterio-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate salt, 3(R)-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-7-yl-5,5,6,6-d4]-4-(2,4,5-trifluorophenyl)butan-1-one phosphate salt, (3R)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl-5,5,6,6-d4]-4-(2,4,5-trifluorophenyl)-1-butanone phosphate, Sitagliptin-D4 phosphate (5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl-5,5,6,6-D4)
• CAS: 1432063-88-1

Beschreibung

Applications A trizolopyrazine dipeptidyl peptidase IV inhibitor. It has recently been approved for the therapy of type II diabetes.
References Kim, D., et al.: J. Med. Chem., 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol., 521 164 (2005), Bergman, A., et al: Clin. Ther., 28, 55 (2006).

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 509.33
• Formel: C₁₆H₁₄D₄F₆N₅O₅P
• Farbe/Form: Off-White
• InChl: InChI=1S/C16H15F6N5O.H3O4P/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22;1-5(2,3)4/h4,6,9H,1-3,5,7,23H2;(H3,1,2,3,4)/t9-;/m1./s1/i1D2,2D2
• InChI Key: InChIKey=SHWZYHNHAUKDOV-JBNLRCFGSA-N
• SMILES: O=P(=O)OO.[2H]C1([2H])N(C(=O)C[C@H](N)Cc2cc(F)c(F)cc2F)Cc2nnc(C(F)(F)F)n2C1([2H])[2H].[HH]