SP 2509

CAS: 1423715-09-6

Ref. TR-S679000

Produktinformation

• Name: SP 2509
• Synonyme: 3-(4-Morpholinylsulfonyl)-Benzoic Acid (2E)-2-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazide, BHC 110 inhibitor VII, Histone Lysine Demethylase Inhibitor XIV, KIAA 1718 inhibitor VII, LSD 1 inhibitor VII
• Marke: TRC

Beschreibung

Applications SP 2509 reduces the effect of the LSD1 binding to CoREST, resulting in increased methylation of H3K4 and driving increased expression of p21, p27 and CCAAT/enhancer binding protein α in acute myeloid leukemia cells. Anti-leukemia agent.
References Sorna, V. et al.: J. Med. Chem., 56, 9496 (2013); Fiskus, W. et al.: Leukemia, 11, 2155 (2014);

Chemische Eigenschaften

• Molekulargewicht: 437.9
• Formel: C₁₉H₂₀ClN₃O₅S
• Farbe/Form: Neat
• InChl: InChI=1S/C19H20ClN3O5S/c1-13(17-12-15(20)5-6-18(17)24)21-22-19(25)14-3-2-4-16(11-14)29(26,27)23-7-9-28-10-8-23/h2-6,11-12,24H,7-10H2,1H3,(H,22,25)/b21-13+