Spironolactone

CAS: 52-01-7

Ref. TR-S683000

Produktinformation

• Name: Spironolactone
• Synonyme: Abbolactone, Aldace, Aldactone, Aldactone A, Aldopur, Almatol, Altex, Aquareduct, Berlactone, Deverol, Diatensec, Dira, Duraspiron, Euteberol, Lacalmin, Lacdene, Laractone, NSC 150399, Nefurofan, Novo-Spiroton, Osiren, Osyrol, Quimolactona, SC 9420, Sagisal, Sincomen, Spiresis, Spiretic, Spiridon, Spiro-Tablinen, Spiroctan, Spiroderm, Spirolactone, Spirolang, Spirolone, Spirone, Spironol, Spironolactone A, Supra-Puren, Suracton, Uractone, Urusonin, Verospiron, Verospirone, Xenalon,Spiro[17H-cyclopenta[a]phenanthrene-17,2'(5'H)-furan], pregn-4-ene-21-carboxylic acid deriv., Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)-, 17alpha-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7alpha-mercapto-3-oxo-, gamma-lactone, acetate (6CI,8CI), 17-Hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic acid gamma-lactone 7-acetate, 3-(3-Oxo-7alpha-acetylthio-17beta-hydroxy-4-androsten-17alpha-yl)propionic acid-gamma-lactone, 3-(3-keto-7alpha-Acetylthio-17beta-hydroxy-4-androsten-17alpha-yl)propionic acid lactone, 3'-(3-Oxo-7alpha-acetylthio-17beta-hydroxyandrost-4-en-17alpha-yl)-propionic acid lactone, 7alpha-(Acetylthio)-17-hydroxy-3-oxo-17alpha-pregn-4-ene-21-carboxylic acid gamma-lactone, 7alpha-Acetylthio-3-oxo-17alpha-pregn-4-ene-21,17beta-carbolactone, (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxo-pregn-4-ene-21-carboxylic acid γ-lactone, 17-Hydroxy-7-alpha-mercapto-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid-gamma-lactone-7-acetate, 17-Hydroxy-7α-mercapto-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone 7-acetate, 17α-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7α-mercapto-3-oxo-, γ-lactone, acetate, 3'-(3-Oxo-7α-acetylthio-17β-hydroxyandrost-4-en-17α-yl)-propionic acid lactone, 3-(3-Oxo-7α-acetylthio-17β-hydroxy-4-androsten-17α-yl)propionic acid-γ-lactone, 3-(3-keto-7α-Acetylthio-17β-hydroxy-4-androsten-17α-yl)propionic acid lactone, 7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-, 7α-(Acetylthio)-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone, 7α-Acetylthio-3-oxo-17α-pregn-4-ene-21,17β-carbolactone, Espironolactona, Nsc 150399, Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, γ-lactone, (7α,17α)-, S-(10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl) ethanethioate, S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate, S-[(7R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate, Sc 9420, Spiro[17H-cyclopenta[a]phenanthrene-17,2′(5′H)-furan], pregn-4-ene-21-carboxylic acid deriv., Spironolacton, Xenalon, carbolactone

Beschreibung

Applications It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome.
References Sutter, J.L., et al.: Anal. Profiles Drug Subs., 4, 431 (1975),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 416.57
• Formel: C₂₄H₃₂O₄S
• Farbe/Form: Off-White
• InChl: InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1
• InChI Key: InChIKey=LXMSZDCAJNLERA-ZHYRCANASA-N
• SMILES: CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)[C@@H]21