SRT 1460 TFA Salt

CAS: 925432-73-1

Ref. TR-S684450

Produktinformation

• Name: SRT 1460 TFA Salt
• Synonyme: 3,4,5-Trimethoxy-N-[2-[3-(1-piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-benzamide Trifluoroacetic Acid Salt
• Marke: TRC

Beschreibung

Applications SRT 1460 is a drug intended as a small-molecule activator of the sirtuin subtype SIRT1. it was found to improve insulin sensitivity and lower plasma glucose levels in fat, muscle and liver tissue, and increased mitochondrial and metabolic function.
References Milne, J., et al.: Nature, 450, 712 (7170); Pacholec, M., et al.: J. BIol. Chem., 285, 8340 (2010); Dai, H., et al.: J. Biol. Chem., 285, 32695 (2010)

Chemische Eigenschaften

• Molekulargewicht: 507.6011402
• Formel: C₂₆H₂₉N₅O₄S•x(C₂HF₃O₂)
• Farbe/Form: Neat
• InChl: InChI=1S/C35H42O12/c1-8-35(47-21(5)39)16-14-27-26-11-9-22-17-23(10-12-24(22)25(26)13-15-34(27,35)6)45-33-31(44-20(4)38)29(43-19(3)37)28(42-18(2)36)30(46-33)32(40)41-7/h1,10,12,17,25-31,33H,9,11,13-16H2,2-7H3/t25-,26+,27+,28+,29?,30?,31?,33+,34-,35-/m0/s1
• SMILES: C#C[C@]1(OC(C)=O)CC[C@@H]2[C@@H]3CCc4cc(O[C@@H]5OC(C(=O)OC)[C@H](OC(C)=O)C(OC(C)=O)C5OC(C)=O)ccc4[C@@H]3CC[C@@]21C