N-Succinyl-5-aminoimidazole-4-carboxamide Ribose Disodium Salt

CAS: 17388-80-6

Ref. TR-S688790

Produktinformation

• Name: N-Succinyl-5-aminoimidazole-4-carboxamide Ribose Disodium Salt
• Synonyme: N-[(5-Amino-1-β-D-ribofuranosyl-1H-imidazol-4-yl)carbonyl]-L-aspartic acid disodium salt, N-(5-Amino-1-ribosyl-4-imidazolecarbonyl)-L-aspartic acid disodium salt, N-[5-Amino-1-(β-D-ribofuranosyl)imidazole-4-carbonyl]-L-aspartic acid disodium salt, Acadesi

Beschreibung

Applications A metabolite of Purine. Purine metabolism by adenylosuccinasedeficient. Since adenosine is a potent inhibitor of neuronal function, depressing the release of several excitatory transmitters and causing direct hyperpolarization of neurons, it was possible that the symptoms seen in adenylosuccinate lyase (ASase) deficient patients could reflect an interference of succinylpurines with neurotransmission.
References Gollub, E.G., et al.: J. Bacteriol., 78, 320 (1959), Srivastava, P.C., et al.: J. Med. Chem., 17, 1207 (1974),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 418.267
• Formel: C₁₃H₁₆N₄Na₂O₉
• Farbe/Form: Neat
• InChl: 2*+1/p-2/t4-,5+,8+,9+,12+, , /m0../s1, /q, /h3-5,8-9,12,18,21-22H,1-2,14H2,(H,16,23)(H,19,20)(H,24,25), , InChI=1S/C13H18N4O9.2Na/c14-10-7(11(23)16-4(13(24)25)1-6(19)20)15-3-17(10)12-9(22)8(21)5(2-18)26-12,
• InChI Key: InChIKey=ZZPKVAPCMROQPH-KGBHUAOWSA-L
• SMILES: Nc1c(C(=O)N[C@@H](CC(=O)O[Na])C(=O)O[Na])ncn1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O