Taurodeoxycholic-2,2,3,4,4-d5 Acid (d5 major)

CAS: 516-50-7

Ref. TR-T009002

Produktinformation

• Name: Taurodeoxycholic-2,2,3,4,4-d5 Acid (d5 major)
• Synonyme: 2-[[(3a,5ß,12ß)-3,12-Dihydroxy-24-oxocholan-24-yl]amino]ethanesulfonic Acid-d5, N-(3a,12a-Dihydroxy-5ß-cholan-24-oyl)taurine-d5, Deoxycholyltaurine-d5, Deoxytaurocholic-d5 Acid, Taurodesoxycholic-d5 Acid, Tudcabil-d5, 2-[[(3α,5β,12α)-3,12-Dihydroxy-24-oxocholan-24-yl]amino]ethanesulfonic acid, 3α,12α-Dihydroxy-5β-cholanic acid-24-taurine, Cholane, ethanesulfonic acid deriv., Deoxycholyltaurine, Deoxytaurocholic acid, Ethanesulfonic acid, 2-(((3alpha,5beta,12alpha)-3,12-dihydroxy-24-oxocholan-24-yl)amino)-, Ethanesulfonic acid, 2-[[(3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl]amino]-, N-(3a,12a-dihydroxy-5b-cholan-24-oyl)-Taurine, Taurine, N-(3α,12α-dihydroxy-5β-cholan-24-oyl)-, Taurodeoxycholic acid, Taurodesoxycholic acid, Tudcabil

Beschreibung

Applications Deoxycholyltaurine rescues human colon cancer cells from apoptosis by activating EGFR-dependent PI3K/Akt signaling.
References Cheng, K., et al.: Biochem. J., 330, 353 (1998), Cheng, K., et al.: Cancer Res., 63, 6744 (2003), Bellacosa, A., et al.: Adv. Cancer Res., 94, 29 (2005), Cheng, K., et al.: Biochem. Pharmacol., 70, 1035 (2005), Fang, D., et al.: J. Biol. Chem., 282, 11221 (2007),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 504.73
• Formel: C₂₆H₄₀D₅NO₆S
• Farbe/Form: White To Off-White
• InChl: InChI=1S/C26H45NO6S/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-/m1/s1/i10D2,14D2,18D
• InChI Key: InChIKey=AWDRATDZQPNJFN-ILYQYKGZSA-N
• SMILES: [2H]C1([2H])C[C@]2(C)[C@H]3C[C@H](O)[C@@]4(C)[C@@H](CC[C@@H]4[C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@@H]3CC[C@@H]2C([2H])([2H])[C@]1([2H])O