(R)-(+)-Thiolactomycin

CAS: 82079-32-1

Ref. TR-T350880

Produktinformation

• Name: (R)-(+)-Thiolactomycin
• Synonyme: (5R)-4-hydroxy-3,5-dimethyl-5-[(1E)-2-methylbuta-1,3-dienyl]thiophen-2-one, (+)-Thiolactomycin, (5R)-4-Hydroxy-3,5-dimethyl-5-[(1E)-2-methyl-1,3-butadien-1-yl]-2(5H)-thiophenone, 2(5H)-Thiophenone, 4-hydroxy-3,5-dimethyl-5-(2-methyl-1,3-butadienyl)-, [R-(E)]-, 2(5H)-Thiophenone, 4-hydroxy-3,5-dimethyl-5-[(1E)-2-methyl-1,3-butadien-1-yl]-, (5R)-, 2(5H)-Thiophenone, 4-hydroxy-3,5-dimethyl-5-[(1E)-2-methyl-1,3-butadienyl]-, (5R)-, 3(2H)-thiophenone, 5-hydroxy-2,4-dimethyl-2-[(1E)-2-methyl-1,3-butadien-1-yl]-, (2R)-, Antibiotic 2-200

Beschreibung

Applications (R)-(+)-Thiolactomycin is a natural product inhibitor of β-Ketoacyl-AcpM Synthase A (KasA). It inhibits the synthesis of mycolic acid which is a major cell wall component of Mycobacterium tuberculosis. Also an inhibitor of D-Aspartate oxidase (DDO).
References Kapilashrami, K., et al.: J. Biol. Chem., 288, 6045 (2013); Paneerselvam, V., et al.: J. Pharm. Res., 4, 4618 (2011); Katane, M., et al.: Biochimie, 92, 1371 (2010)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 210.29
• Formel: C₁₁H₁₄O₂S
• Farbe/Form: Off White To Light Beige
• InChl: InChI=1S/C11H14O2S/c1-5-7(2)6-11(4)9(12)8(3)10(13)14-11/h5-6,12H,1H2,2-4H3/b7-6+/t11-/m1/s1
• InChI Key: InChIKey=SYQNUQSGEWNWKV-JMEBYUIHSA-N
• SMILES: C=C/C(C)=C\[C@@]1(C)SC(=O)C(C)=C1O