Topotecan-d6 Hydrochloride

CAS: 1044746-98-6

Ref. TR-T542504

Produktinformation

• Name: Topotecan-d6 Hydrochloride
• Synonyme: (19S)-8-[[bis(trideuteriomethyl)amino]methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione;hydrochloride

Beschreibung

Applications Topotecan-d6 Hydrochloride is the labeled analogue of Topotecan Hydrochloride (T542500), a DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic. Topotecan hydrochloride is a chemotherapy agent that is a topoisomerase 1 inhibitor.
References Beijnen, J.H., et al.: J. Pharm. Biomed. Anal., 8, 789 (1990); BeiKingsburg, W.D., et al.: J. Med. Chem., 34, 98 (1991); Rowinsky, E.K., et al.: J. Clin. Oncol., 10, 647 (1992)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 463.944
• Formel: C₂₃D₆H₁₇N₃O₅·HCl
• Farbe/Form: Neat
• InChl: InChI=1S/C23H23N3O5.ClH/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20;/h5-8,27,30H,4,9-11H2,1-3H3;1H/t23-;/m0./s1/i2D3,3D3
• InChI Key: InChIKey=DGHHQBMTXTWTJV-ZSZCRZDTSA-N
• SMILES: Cl.[2H]C([2H])([2H])N(Cc1c(O)ccc2nc3c(cc12)Cn1c-3cc2c(c1=O)COC(=O)[C@]2(O)CC)C([2H])([2H])[2H]