Produktinformation
- N-alpha-Tosyl-L-phenylalanylchloromethane
- (S)-N-(4-Chloro-3-oxo-1-phenylbutan-2-yl)-4-methylbenzenesulfonamide
- <span class="text-smallcaps">L</span>-1-Chloro-3-tosylamidyl-4-phenyl-2-butanone
- <span class="text-smallcaps">L</span>-1-Chloro-4-phenyl-3-p-tolylsulfonamidobutan-2-one
- <span class="text-smallcaps">L</span>-1-Chloro-4-phenyl-3-toluene-p-sulfonamido-2-butanone
- <span class="text-smallcaps">L</span>-1-Tosylamide-2-phenylethylchloromethyl ketone
- <span class="text-smallcaps">L</span>-1-Tosylamido-2-phenylethyl chloromethyl ketone
- <span class="text-smallcaps">L</span>-Tolylsulfonylphenylalanyl chloromethyl ketone
- Benzenesulfonamide, N-((1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl)-4-methyl-
- Benzenesulfonamide, N-(3-chloro-2-oxo-1-(phenylmethyl)propyl)-4-methyl-, (S)-
- Mehr Synonyme anzeigen
- Brn 2895215
- L-1-Tosylamido-2-phenylethyl chloromethyl ketone
- N-(4-chloro-3-oxo-1-phenylbutan-2-yl)-4-methylbenzenesulfonamide
- N-(p-Toluenesulfonyl)-<span class="text-smallcaps">L</span>-phenylalanylchloromethane
- N-Tosyl-<span class="text-smallcaps">L</span>-phenylalaninechloromethane
- N-Tosyl-<span class="text-smallcaps">L</span>-phenylalanyl chloromethyl ketone
- N-Tosyl-<span class="text-smallcaps">L</span>-phenylalanylchloromethane
- N-Tosyl-L-phenylalanine chloromethyl ketone
- N-Tosyl-L-phenylalanyl Chloromethyl Ketone
- N-Tosylphenylalanine chloromethyl ketone
- N-[(1S)-3-Chloro-2-oxo-1-(phenylmethyl)propyl]-4-methylbenzenesulfonamide
- N-[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]-4-methylbenzenesulfonamide
- N-α-Tosyl-<span class="text-smallcaps">L</span>-phenylalanylchloromethane
- N<sup>α</sup>-Tosyl-<span class="text-smallcaps">L</span>-phenylalanine chloromethyl ketone
- Tosylphenylalanine chloromethyl ketone
- Tosylphenylalanyl chloromethyl ketone
- Tosylphenylalanylchloromethane
- Tpck
- l-N-(alpha-(Chloroacetyl)phenethyl)-p-toluenesulfonamide
- p-Toluenesulfonamide, N-(alpha-(chloroacetyl)phenethyl)-, (-)-
- p-Toluenesulfonamide, N-[α-(chloroacetyl)phenethyl]-, <span class="text-smallcaps">L</span>-
- α-N-Tosyl-<span class="text-smallcaps">L</span>-phenylalanine chloromethyl ketone
- p-Toluenesulfonamide, N-[α-(chloroacetyl)phenethyl]-, L-
- N-Tosyl-L-phenylalanylchloromethane
Applications N-α-Tosyl-L-phenylalanylchloromethane is a proteinase inhibitors with apoptotic function. Studies have shown that it induces caspase-dependent apoptosis in Epstein-Barr virus (EBV)-transformed human B cell lines with release of pro-apoptotic proteins from mitochondria. It also results in down-regulation of the anti-apoptotic proteins and caspase-dependent cleavage of two anti-apoptotic proteins. It promotes dephosphorylation of p53 on serine residues.
References Jitkaew, S. et al.: J. Bio. Chem., 284, 27827 (2009); Kim, K. et al.: Biochem. Biophys. Res. Comm., 306, 954 (2003); Griscavage, J. et al.: Biochem. Biophys. Res. Comm., 215, 721 (1995)
Chemische Eigenschaften
Technische Anfrage zu: TR-T686000 N-alpha-Tosyl-L-phenylalanylchloromethane
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